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History: Diabetes Mellitus (DM) triggers an abnormal reaction of free of charge-radicals. It improves reactive oxygen species and decreases antioxidants position as well as the β cell injury. Crystal clear kefir was used for DM therapies, even so it confined biomolecular exploration of its bioactive roles. Analysis aimed to research the consequences of distinct kefir about the biomolecular mother nature of the glycemic status of T2DM in Bandung. Approaches: The randomized pretest-posttest Command group was carried out by 106 T2DM clients. Investigate was carried out in many hospitals in Bandung and Cimahi, West Java from 2012–2013. Samples ended up divided randomly into a few teams: (1) T2DM with HbA1c < 7 was fed a typical diet regime, supplemented with two hundred ml/working day of apparent kefir, (2) T2DM with HbA1c > 7 fed regular diet program and supplemented two hundred ml/working day by crystal clear kefir, (three) T2DM with HbA1c was fed an ordinary diet plan like a Management team.